A large body of evidence suggests that two members of the Vaccinium genus, blueberry and cranberry, may offer many health benefits because they contain high concentrations of phytochemicals. Among the phytochemicals that will be discussed in this review are flavonoids and pterostilbene. A growing body of research suggests the phytochemicals in blueberry and cranberry can help reduce the risk for cardiovascular disease through antioxidant, anti-inflammatory, antilipidemic, antihypertensive, and antihyperglycemic effects. Additionally, research suggests that cranberry and blueberry phytochemicals may have beneficial effects on weight and metabolism, as well as cognition and memory. This white paper provides an overview of the evidence and why pteroberry™, a blend of all-trans natural pterostilbene (10%) with organic blueberry and cranberry extracts (90%) should be considered.